Drug interactions
Erythromycin + Indacaterol inhaled
Severity: Moderate
Erythromycin and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and P-gp, modestly raising indacaterol exposure, and both agents can affect the QT interval. At the recommended dose the increase in exposure is not considered clinically significant, though additive cardiac effects remain possible.
What this interaction means in plain words
Erythromycin and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 and P-gp inhibition by erythromycin raises indacaterol exposure, with additive QT effects.
What to do
No dose adjustment is needed at the usual dose; monitor for palpitations, tremor and hypokalemia. Use an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Erythromycin and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and P-gp, modestly raising indacaterol exposure, and both agents can affect the QT interval. At the recommended dose the increase in exposure is not considered clinically significant, though additive cardiac effects remain possible.
How serious is the interaction between Erythromycin and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed at the usual dose; monitor for palpitations, tremor and hypokalemia. Use an ECG if other QT risk factors are present.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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