Drug interactions
Erythromycin + Isradipine
Severity: Moderate
Erythromycin and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can raise isradipine exposure because both are handled by CYP3A4. Higher levels may cause excessive vasodilation with hypotension, dizziness, peripheral edema and reflex tachycardia.
What this interaction means in plain words
Erythromycin and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits intestinal and hepatic CYP3A4, reducing first-pass and systemic metabolism of isradipine.
What to do
Monitor blood pressure and heart rate when starting or stopping erythromycin, and reduce the isradipine dose if hypotension or edema develops. Consider a non-CYP3A4-inhibiting antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Isradipine?
MediHelp rates the interaction as moderate. Erythromycin and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can raise isradipine exposure because both are handled by CYP3A4. Higher levels may cause excessive vasodilation with hypotension, dizziness, peripheral edema and reflex tachycardia.
How serious is the interaction between Erythromycin and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping erythromycin, and reduce the isradipine dose if hypotension or edema develops. Consider a non-CYP3A4-inhibiting antibiotic if feasible.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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