Drug interactions
Erythromycin + Ixabepilone
Severity: Major
Erythromycin and Ixabepilone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase ixabepilone exposure, raising the risk of neutropenia, neuropathy and other toxicities. Ixabepilone is extensively cleared by CYP3A4.
What this interaction means in plain words
Erythromycin and Ixabepilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of ixabepilone.
What to do
Use a non-inhibiting antibiotic instead. If unavoidable, reduce the ixabepilone dose per labeling and monitor blood counts and neurotoxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Ixabepilone?
MediHelp rates the interaction as major. Erythromycin and Ixabepilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may increase ixabepilone exposure, raising the risk of neutropenia, neuropathy and other toxicities. Ixabepilone is extensively cleared by CYP3A4.
How serious is the interaction between Erythromycin and Ixabepilone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inhibiting antibiotic instead. If unavoidable, reduce the ixabepilone dose per labeling and monitor blood counts and neurotoxicity.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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