Drug interactions
Erythromycin + Lansoprazole
Severity: Minor
Erythromycin and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may modestly increase lansoprazole concentrations, because lansoprazole is partly cleared via CYP3A4. Given the wide therapeutic index of lansoprazole, the effect is rarely clinically relevant.
What this interaction means in plain words
Erythromycin and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Erythromycin inhibits CYP3A4, a secondary metabolic pathway of lansoprazole.
What to do
No routine adjustment is needed; this combination is commonly used in H. pylori regimens with clarithromycin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Erythromycin with Lansoprazole?
MediHelp rates the interaction as minor. Erythromycin and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin may modestly increase lansoprazole concentrations, because lansoprazole is partly cleared via CYP3A4. Given the wide therapeutic index of lansoprazole, the effect is rarely clinically relevant.
How serious is the interaction between Erythromycin and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; this combination is commonly used in H. pylori regimens with clarithromycin.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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