Drug interactions
Erythromycin + Microbiota
Severity: Moderate
Erythromycin and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota products contain live bacterial spores, and antibacterials such as erythromycin may kill or suppress them. This can reduce colonization and the preventive effect against recurrent Clostridioides difficile infection.
What this interaction means in plain words
Erythromycin and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity directly antagonizes the live bacterial content of the product.
What to do
Complete the antibiotic course and allow the labeled washout interval, typically a few days, before starting the microbiota product.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Microbiota?
MediHelp rates the interaction as moderate. Erythromycin and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota products contain live bacterial spores, and antibacterials such as erythromycin may kill or suppress them. This can reduce colonization and the preventive effect against recurrent Clostridioides difficile infection.
How serious is the interaction between Erythromycin and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the antibiotic course and allow the labeled washout interval, typically a few days, before starting the microbiota product.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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