Drug interactions
Erythromycin + Mipomersen
Severity: Moderate
Erythromycin and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver transaminases and can cause hepatic steatosis, and erythromycin can also rarely cause liver enzyme elevation or cholestatic hepatitis. Combined use may add to hepatotoxic risk.
What this interaction means in plain words
Erythromycin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential; this is a pharmacodynamic overlap rather than an established kinetic interaction.
What to do
Monitor liver enzymes and bilirubin during coadministration, and withhold or reassess therapy if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Mipomersen?
MediHelp rates the interaction as moderate. Erythromycin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises liver transaminases and can cause hepatic steatosis, and erythromycin can also rarely cause liver enzyme elevation or cholestatic hepatitis. Combined use may add to hepatotoxic risk.
How serious is the interaction between Erythromycin and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin during coadministration, and withhold or reassess therapy if transaminases rise significantly.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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