Drug interactions
Erythromycin + Neomycin po
Severity: Minor
Erythromycin and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so any increase in its exposure through P-glycoprotein inhibition is unlikely to be clinically important. Oral neomycin may reduce gut bacteria and affect erythromycin absorption or activity, but this effect is not well characterized and is not a recognized hazard.
What this interaction means in plain words
Erythromycin and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical P-glycoprotein inhibition by erythromycin; clinical relevance is unestablished given minimal oral neomycin absorption.
What to do
No specific action is needed. Consider renal function and hearing in patients with impaired renal function or prolonged neomycin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Neomycin po?
MediHelp rates the interaction as minor. Erythromycin and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so any increase in its exposure through P-glycoprotein inhibition is unlikely to be clinically important. Oral neomycin may reduce gut bacteria and affect erythromycin absorption or activity, but this effect is not well characterized and is not a recognized hazard.
How serious is the interaction between Erythromycin and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Consider renal function and hearing in patients with impaired renal function or prolonged neomycin use.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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