Drug interactions
Erythromycin + Nirogacestat
Severity: Major
Erythromycin and Nirogacestat: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase nirogacestat exposure, increasing risk of diarrhea, hepatotoxicity and other adverse effects.
What this interaction means in plain words
Erythromycin and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Nirogacestat belongs to Oncology.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of nirogacestat.
What to do
Avoid moderate CYP3A inhibitors and choose an alternative antibiotic. If unavoidable, monitor liver tests and gastrointestinal toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Nirogacestat
Frequently asked questions
Can I take Erythromycin with Nirogacestat?
MediHelp rates the interaction as major. Erythromycin and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may increase nirogacestat exposure, increasing risk of diarrhea, hepatotoxicity and other adverse effects.
How serious is the interaction between Erythromycin and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid moderate CYP3A inhibitors and choose an alternative antibiotic. If unavoidable, monitor liver tests and gastrointestinal toxicity.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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