Drug interactions
Erythromycin + Nitrendipine
Severity: Moderate
Erythromycin and Nitrendipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase nitrendipine exposure because nitrendipine undergoes extensive CYP3A4 first-pass metabolism. This may lead to hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Erythromycin and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits intestinal and hepatic CYP3A4, reducing nitrendipine metabolism.
What to do
Monitor blood pressure and symptoms of vasodilation and reduce the nitrendipine dose if needed. Consider a non-inhibiting antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Nitrendipine?
MediHelp rates the interaction as moderate. Erythromycin and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase nitrendipine exposure because nitrendipine undergoes extensive CYP3A4 first-pass metabolism. This may lead to hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Erythromycin and Nitrendipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of vasodilation and reduce the nitrendipine dose if needed. Consider a non-inhibiting antibiotic.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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