Drug interactions
Erythromycin + Octreotide
Severity: Moderate
Erythromycin and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and combining it with erythromycin may add to arrhythmia risk. The risk is greater with electrolyte imbalance or heart disease.
What this interaction means in plain words
Erythromycin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Octreotide belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization, with octreotide-related bradycardia contributing to risk.
What to do
Check ECG and electrolytes at baseline in at-risk patients. Monitor heart rate and QTc during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Erythromycin with Octreotide?
MediHelp rates the interaction as moderate. Erythromycin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and combining it with erythromycin may add to arrhythmia risk. The risk is greater with electrolyte imbalance or heart disease.
How serious is the interaction between Erythromycin and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline in at-risk patients. Monitor heart rate and QTc during combined use.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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