Drug interactions
Erythromycin + Olodaterol inhaled
Severity: Moderate
Erythromycin and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and olodaterol, a long-acting beta2 agonist, can affect cardiac repolarization and cause hypokalemia and tachycardia. Combined use may increase the risk of ventricular arrhythmias, though systemic exposure from inhaled olodaterol is low.
What this interaction means in plain words
Erythromycin and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on QT interval and cardiovascular stimulation.
What to do
Monitor for palpitations and arrhythmia, and check potassium in patients at risk. Consider an ECG in patients with existing QT prolongation or cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Erythromycin and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin prolongs the QT interval and olodaterol, a long-acting beta2 agonist, can affect cardiac repolarization and cause hypokalemia and tachycardia. Combined use may increase the risk of ventricular arrhythmias, though systemic exposure from inhaled olodaterol is low.
How serious is the interaction between Erythromycin and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia, and check potassium in patients at risk. Consider an ECG in patients with existing QT prolongation or cardiac disease.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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