Drug interactions
Erythromycin + Paclitaxel protein bound
Severity: Moderate
Erythromycin and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8 and CYP3A4 and is a P-glycoprotein substrate, so erythromycin may raise its exposure. Higher levels could increase neutropenia and neuropathy, although the clinical effect of erythromycin is not well quantified.
What this interaction means in plain words
Erythromycin and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4 and P-glycoprotein, which may reduce paclitaxel clearance.
What to do
Monitor blood counts and signs of neuropathy, and consider an alternative antibiotic that does not inhibit CYP3A4. Adjust the paclitaxel dose according to toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Erythromycin and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is metabolized by CYP2C8 and CYP3A4 and is a P-glycoprotein substrate, so erythromycin may raise its exposure. Higher levels could increase neutropenia and neuropathy, although the clinical effect of erythromycin is not well quantified.
How serious is the interaction between Erythromycin and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy, and consider an alternative antibiotic that does not inhibit CYP3A4. Adjust the paclitaxel dose according to toxicity.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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