Drug interactions
Erythromycin + Parecoxib
Severity: Minor
Erythromycin and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is rapidly converted to valdecoxib, which is partly metabolized by CYP3A4, so erythromycin may raise valdecoxib levels. This could increase the risk of NSAID-related adverse effects, such as gastrointestinal, renal and cardiovascular events.
What this interaction means in plain words
Erythromycin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4, which contributes to valdecoxib metabolism.
What to do
No routine dose change is needed. Use the lowest effective parecoxib dose and monitor for NSAID adverse effects, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Parecoxib?
MediHelp rates the interaction as minor. Erythromycin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is rapidly converted to valdecoxib, which is partly metabolized by CYP3A4, so erythromycin may raise valdecoxib levels. This could increase the risk of NSAID-related adverse effects, such as gastrointestinal, renal and cardiovascular events.
How serious is the interaction between Erythromycin and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Use the lowest effective parecoxib dose and monitor for NSAID adverse effects, especially in renal impairment.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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