Drug interactions
Erythromycin + Penicillin g aqueous
Severity: Minor
Erythromycin and Penicillin g aqueous: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic macrolides have been theorized to blunt the activity of bactericidal beta-lactams that depend on actively dividing bacteria. Clinical evidence of reduced efficacy is inconsistent and largely anecdotal.
What this interaction means in plain words
Erythromycin and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism between a bacteriostatic protein synthesis inhibitor and a bactericidal cell wall inhibitor.
What to do
No routine change is needed; if treating a severe infection such as meningitis or endocarditis, prefer a regimen that does not rely on combining the two, or give the beta-lactam first.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Penicillin g aqueous?
MediHelp rates the interaction as minor. Erythromycin and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bacteriostatic macrolides have been theorized to blunt the activity of bactericidal beta-lactams that depend on actively dividing bacteria. Clinical evidence of reduced efficacy is inconsistent and largely anecdotal.
How serious is the interaction between Erythromycin and Penicillin g aqueous?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; if treating a severe infection such as meningitis or endocarditis, prefer a regimen that does not rely on combining the two, or give the beta-lactam first.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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