Drug interactions
Erythromycin + Ponatinib
Severity: Moderate
Erythromycin and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein and may modestly increase erythromycin exposure. Erythromycin, as a CYP3A4 inhibitor, may also increase ponatinib levels and its adverse effects, including hepatotoxicity, pancreatitis and cardiovascular events.
What this interaction means in plain words
Erythromycin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Ponatinib belongs to Oncology.
Why it happens
Ponatinib inhibits P-glycoprotein efflux of erythromycin, and erythromycin inhibits CYP3A4 metabolism of ponatinib.
What to do
Monitor for erythromycin adverse effects and for ponatinib toxicity, including liver enzymes and lipase. Consider an alternative antibiotic that does not inhibit CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Erythromycin with Ponatinib?
MediHelp rates the interaction as moderate. Erythromycin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-glycoprotein and may modestly increase erythromycin exposure. Erythromycin, as a CYP3A4 inhibitor, may also increase ponatinib levels and its adverse effects, including hepatotoxicity, pancreatitis and cardiovascular events.
How serious is the interaction between Erythromycin and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erythromycin adverse effects and for ponatinib toxicity, including liver enzymes and lipase. Consider an alternative antibiotic that does not inhibit CYP3A4.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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