Drug interactions
Erythromycin + Triamcinolone acetonide injectable
Severity: Moderate
Erythromycin and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may raise systemic triamcinolone exposure by inhibiting CYP3A4, increasing corticosteroid effects such as adrenal suppression and Cushingoid features. The effect is most relevant with repeated or high-dose injections, and is less likely with a single short-term injection.
What this interaction means in plain words
Erythromycin and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated triamcinolone metabolism by erythromycin.
What to do
Monitor for corticosteroid excess with repeated dosing, and consider an alternative antibiotic or a longer dosing interval for triamcinolone if prolonged coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erythromycin and Triamcinolone acetonide injectable, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Erythromycin and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may raise systemic triamcinolone exposure by inhibiting CYP3A4, increasing corticosteroid effects such as adrenal suppression and Cushingoid features. The effect is most relevant with repeated or high-dose injections, and is less likely with a single short-term injection.
How serious is the interaction between Erythromycin and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess with repeated dosing, and consider an alternative antibiotic or a longer dosing interval for triamcinolone if prolonged coadministration is needed.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
