Drug interactions
Erythromycin + Typhoid vaccine live
Severity: Moderate
Erythromycin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral typhoid vaccine (Ty21a) is an attenuated bacterium, and antibacterial activity may reduce its replication and the resulting immune response. Erythromycin is an antibiotic with activity against some bacteria, so vaccine effectiveness may be reduced.
What this interaction means in plain words
Erythromycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic activity may inhibit viability of the live attenuated bacteria, reducing vaccine immunogenicity.
What to do
Delay the live oral typhoid vaccine until antibiotic therapy is finished, with an interval of at least 24 to 72 hours as per labeling, or use the inactivated injectable vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Erythromycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live oral typhoid vaccine (Ty21a) is an attenuated bacterium, and antibacterial activity may reduce its replication and the resulting immune response. Erythromycin is an antibiotic with activity against some bacteria, so vaccine effectiveness may be reduced.
How serious is the interaction between Erythromycin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay the live oral typhoid vaccine until antibiotic therapy is finished, with an interval of at least 24 to 72 hours as per labeling, or use the inactivated injectable vaccine.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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