Drug interactions
Erythromycin + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Erythromycin and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may modestly raise vilanterol exposure through CYP3A4 and P-gp inhibition, and both can affect QT interval. Cardiovascular effects of the beta-agonist such as palpitations and tachycardia may be amplified.
What this interaction means in plain words
Erythromycin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition raising vilanterol levels with potential additive QT effects.
What to do
Monitor heart rate, symptoms of palpitations and ECG in patients with cardiac risk factors. Consider a non-macrolide antibiotic in patients with QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Erythromycin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may modestly raise vilanterol exposure through CYP3A4 and P-gp inhibition, and both can affect QT interval. Cardiovascular effects of the beta-agonist such as palpitations and tachycardia may be amplified.
How serious is the interaction between Erythromycin and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, symptoms of palpitations and ECG in patients with cardiac risk factors. Consider a non-macrolide antibiotic in patients with QT risk.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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