Drug interactions
Erythromycin + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Erythromycin and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may modestly increase vilanterol and fluticasone furoate exposure via CYP3A4 inhibition, and QT effects may be additive. Beta-agonist cardiovascular effects may be increased.
What this interaction means in plain words
Erythromycin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition raising vilanterol and fluticasone exposure with possible additive QT effects.
What to do
Monitor heart rate and ECG in patients with cardiac risk factors, and consider a non-macrolide antibiotic if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Erythromycin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may modestly increase vilanterol and fluticasone furoate exposure via CYP3A4 inhibition, and QT effects may be additive. Beta-agonist cardiovascular effects may be increased.
How serious is the interaction between Erythromycin and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac risk factors, and consider a non-macrolide antibiotic if QT risk is high.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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