Drug interactions
Erythromycin base + Insulin degludec-liraglutide
Severity: Minor
Erythromycin base and Insulin degludec-liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin has been associated with occasional hypoglycemia, particularly with insulin or insulin secretagogues. The effect is uncommon and the evidence is limited.
What this interaction means in plain words
Erythromycin base and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin acts as a motilin agonist that speeds gastric emptying, which may alter postprandial glucose; effects on insulin secretion are not firmly established.
What to do
Monitor blood glucose during short courses of erythromycin. Adjust the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Erythromycin base with Insulin degludec-liraglutide?
MediHelp rates the interaction as minor. Erythromycin base and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin has been associated with occasional hypoglycemia, particularly with insulin or insulin secretagogues. The effect is uncommon and the evidence is limited.
How serious is the interaction between Erythromycin base and Insulin degludec-liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during short courses of erythromycin. Adjust the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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