Drug interactions
Erythromycin base + Prednisolone
Severity: Minor
Erythromycin base and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and P-glycoprotein and can modestly raise prednisolone exposure, with a smaller effect than seen with methylprednisolone. Increased steroid effects are possible with prolonged use.
What this interaction means in plain words
Erythromycin base and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by erythromycin reduces prednisolone clearance.
What to do
No routine dose change is needed for short courses. Monitor for corticosteroid adverse effects if both are used for extended periods.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Erythromycin base with Prednisolone?
MediHelp rates the interaction as minor. Erythromycin base and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and P-glycoprotein and can modestly raise prednisolone exposure, with a smaller effect than seen with methylprednisolone. Increased steroid effects are possible with prolonged use.
How serious is the interaction between Erythromycin base and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for short courses. Monitor for corticosteroid adverse effects if both are used for extended periods.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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