Drug interactions
Erythromycin base + Tadalafil
Severity: Moderate
Erythromycin base and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and raises tadalafil exposure. This may increase hypotension, flushing, headache and priapism.
What this interaction means in plain words
Erythromycin base and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated tadalafil metabolism by erythromycin.
What to do
For ED, use the lower labeled tadalafil dose and extend the dosing interval. For PAH, monitor tolerance and blood pressure, and consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Erythromycin base with Tadalafil?
MediHelp rates the interaction as moderate. Erythromycin base and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and raises tadalafil exposure. This may increase hypotension, flushing, headache and priapism.
How serious is the interaction between Erythromycin base and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For ED, use the lower labeled tadalafil dose and extend the dosing interval. For PAH, monitor tolerance and blood pressure, and consider an alternative antibiotic.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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