Drug interactions
Erythromycin base + Telavancin
Severity: Moderate
Erythromycin base and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may add to the risk of torsades de pointes. The risk rises with electrolyte disturbance, structural heart disease, or other QT-prolonging drugs.
What this interaction means in plain words
Erythromycin base and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of ventricular repolarization; erythromycin blocks the hERG potassium channel.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before starting. Monitor the QTc during treatment, or choose a non-macrolide alternative if the patient has other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Erythromycin base with Telavancin?
MediHelp rates the interaction as moderate. Erythromycin base and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use may add to the risk of torsades de pointes. The risk rises with electrolyte disturbance, structural heart disease, or other QT-prolonging drugs.
How serious is the interaction between Erythromycin base and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before starting. Monitor the QTc during treatment, or choose a non-macrolide alternative if the patient has other risk factors.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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