Drug interactions
Erythromycin ethylsuccinate + Ezogabine
Severity: Moderate
Erythromycin ethylsuccinate and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can prolong the QT interval and has been associated with torsades de pointes. Ezogabine adds a modest QT effect, so the combined risk is higher.
What this interaction means in plain words
Erythromycin ethylsuccinate and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor the ECG and QT interval, and correct electrolyte abnormalities. Consider a non-QT-prolonging antibiotic in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Ezogabine?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can prolong the QT interval and has been associated with torsades de pointes. Ezogabine adds a modest QT effect, so the combined risk is higher.
How serious is the interaction between Erythromycin ethylsuccinate and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and QT interval, and correct electrolyte abnormalities. Consider a non-QT-prolonging antibiotic in patients with other risk factors.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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