Drug interactions
Erythromycin ethylsuccinate + Fluvastatin
Severity: Minor
Erythromycin ethylsuccinate and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin is mainly cleared by CYP2C9, and erythromycin has little effect on its exposure. Any increase in myopathy risk is expected to be small.
What this interaction means in plain words
Erythromycin ethylsuccinate and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak OATP1B1 inhibition by erythromycin; CYP3A4 inhibition is not relevant to fluvastatin.
What to do
No dose change is generally needed. Advise patients to report unexplained muscle pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Fluvastatin?
MediHelp rates the interaction as minor. Erythromycin ethylsuccinate and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvastatin is mainly cleared by CYP2C9, and erythromycin has little effect on its exposure. Any increase in myopathy risk is expected to be small.
How serious is the interaction between Erythromycin ethylsuccinate and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Advise patients to report unexplained muscle pain.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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