Drug interactions
Erythromycin ethylsuccinate + Ifosfamide
Severity: Moderate
Erythromycin ethylsuccinate and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, which may lower ifosfamide activation and potentially reduce efficacy, though it may also decrease toxic metabolite formation. The clinical effect is uncertain.
What this interaction means in plain words
Erythromycin ethylsuccinate and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by erythromycin reduces ifosfamide metabolism.
What to do
Consider an alternative antibiotic such as one without CYP3A4 inhibition. If combined, monitor for response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Ifosfamide?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4, which may lower ifosfamide activation and potentially reduce efficacy, though it may also decrease toxic metabolite formation. The clinical effect is uncertain.
How serious is the interaction between Erythromycin ethylsuccinate and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic such as one without CYP3A4 inhibition. If combined, monitor for response and toxicity.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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