Drug interactions
Erythromycin ethylsuccinate + Metformin-repaglinide
Severity: Major
Erythromycin ethylsuccinate and Metformin-repaglinide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can raise repaglinide levels. This increases the risk of prolonged or severe hypoglycemia.
What this interaction means in plain words
Erythromycin ethylsuccinate and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated repaglinide metabolism.
What to do
Prefer a non-interacting antibiotic. If used together, monitor blood glucose closely and consider reducing the repaglinide dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Metformin-repaglinide?
MediHelp rates the interaction as major. Erythromycin ethylsuccinate and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin inhibits CYP3A4 and can raise repaglinide levels. This increases the risk of prolonged or severe hypoglycemia.
How serious is the interaction between Erythromycin ethylsuccinate and Metformin-repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-interacting antibiotic. If used together, monitor blood glucose closely and consider reducing the repaglinide dose.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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