Drug interactions
Erythromycin ethylsuccinate + Sacubitril-valsartan
Severity: Minor
Erythromycin ethylsuccinate and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is a substrate of hepatic uptake transporters such as OATP1B1, which erythromycin may inhibit. This could modestly raise valsartan exposure and enhance hypotension or renal effects. The clinical significance is likely small.
What this interaction means in plain words
Erythromycin ethylsuccinate and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan, increasing its systemic exposure.
What to do
No dose change is usually needed; monitor blood pressure and renal function when starting or stopping erythromycin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Erythromycin ethylsuccinate and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is a substrate of hepatic uptake transporters such as OATP1B1, which erythromycin may inhibit. This could modestly raise valsartan exposure and enhance hypotension or renal effects. The clinical significance is likely small.
How serious is the interaction between Erythromycin ethylsuccinate and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood pressure and renal function when starting or stopping erythromycin.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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