Drug interactions
Erythromycin ethylsuccinate + Sorafenib
Severity: Major
Erythromycin ethylsuccinate and Sorafenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and also inhibits CYP3A4. With sorafenib, which can prolong QT, the risk of torsades de pointes is increased, and sorafenib exposure may rise slightly.
What this interaction means in plain words
Erythromycin ethylsuccinate and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, plus possible CYP3A4 inhibition by erythromycin raising sorafenib levels.
What to do
Choose a non-macrolide antibiotic with less QT effect when possible. If combined, monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sorafenib
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Sorafenib?
MediHelp rates the interaction as major. Erythromycin ethylsuccinate and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin prolongs the QT interval and also inhibits CYP3A4. With sorafenib, which can prolong QT, the risk of torsades de pointes is increased, and sorafenib exposure may rise slightly.
How serious is the interaction between Erythromycin ethylsuccinate and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-macrolide antibiotic with less QT effect when possible. If combined, monitor ECG and electrolytes.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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