Drug interactions
Erythromycin ethylsuccinate + Triamcinolone
Severity: Moderate
Erythromycin ethylsuccinate and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, which metabolises triamcinolone, and can raise systemic corticosteroid exposure. This can lead to Cushingoid features and adrenal suppression, particularly with repeated injections or prolonged use.
What this interaction means in plain words
Erythromycin ethylsuccinate and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4-mediated clearance of triamcinolone.
What to do
Monitor for corticosteroid excess such as hyperglycaemia, fluid retention and adrenal suppression; consider an alternative antibiotic like azithromycin if prolonged exposure is expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Triamcinolone?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4, which metabolises triamcinolone, and can raise systemic corticosteroid exposure. This can lead to Cushingoid features and adrenal suppression, particularly with repeated injections or prolonged use.
How serious is the interaction between Erythromycin ethylsuccinate and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as hyperglycaemia, fluid retention and adrenal suppression; consider an alternative antibiotic like azithromycin if prolonged exposure is expected.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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