Drug interactions
Erythromycin ethylsuccinate + Vinorelbine
Severity: Moderate
Erythromycin ethylsuccinate and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may increase vinorelbine concentrations. This can lead to more severe neutropenia and neurotoxicity.
What this interaction means in plain words
Erythromycin ethylsuccinate and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4 metabolism of vinorelbine.
What to do
Monitor blood counts and neurotoxicity, or use a non-CYP3A4-inhibiting antibiotic such as azithromycin where suitable. Reduce the vinorelbine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Vinorelbine?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and may increase vinorelbine concentrations. This can lead to more severe neutropenia and neurotoxicity.
How serious is the interaction between Erythromycin ethylsuccinate and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity, or use a non-CYP3A4-inhibiting antibiotic such as azithromycin where suitable. Reduce the vinorelbine dose if toxicity develops.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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