Drug interactions
Erythromycin stearate + Lorlatinib
Severity: Moderate
Erythromycin stearate and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may reduce erythromycin concentrations, potentially weakening antibacterial effect. Lorlatinib exposure may also be raised by erythromycin, a CYP3A4 inhibitor.
What this interaction means in plain words
Erythromycin stearate and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, increasing erythromycin metabolism.
What to do
Monitor for treatment failure of the infection and consider another antibiotic class. Monitor for lorlatinib toxicity such as lipid elevation and CNS effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Erythromycin stearate with Lorlatinib?
MediHelp rates the interaction as moderate. Erythromycin stearate and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may reduce erythromycin concentrations, potentially weakening antibacterial effect. Lorlatinib exposure may also be raised by erythromycin, a CYP3A4 inhibitor.
How serious is the interaction between Erythromycin stearate and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure of the infection and consider another antibiotic class. Monitor for lorlatinib toxicity such as lipid elevation and CNS effects.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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