Drug interactions
Erythromycin stearate + Pazopanib
Severity: Major
Erythromycin stearate and Pazopanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and P-gp, which may increase pazopanib concentrations. Both drugs can also prolong the QT interval, so the combination adds arrhythmic risk as well as toxicity from higher exposure.
What this interaction means in plain words
Erythromycin stearate and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 and P-gp inhibition by erythromycin, plus additive QT prolongation.
What to do
Use a non-interacting antibiotic such as an agent without CYP3A4 or QT effects when possible. If it cannot be avoided, consider reducing pazopanib to 400 mg daily and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Erythromycin stearate with Pazopanib?
MediHelp rates the interaction as major. Erythromycin stearate and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin inhibits CYP3A4 and P-gp, which may increase pazopanib concentrations. Both drugs can also prolong the QT interval, so the combination adds arrhythmic risk as well as toxicity from higher exposure.
How serious is the interaction between Erythromycin stearate and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-interacting antibiotic such as an agent without CYP3A4 or QT effects when possible. If it cannot be avoided, consider reducing pazopanib to 400 mg daily and monitor ECG and electrolytes.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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