Drug interactions
Escitalopram + Ezogabine
Severity: Moderate
Escitalopram and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation and escitalopram also lengthens the QT interval. Combined use may increase proarrhythmic risk.
What this interaction means in plain words
Escitalopram and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Ezogabine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor the ECG at baseline and during dose titration, and correct electrolyte disturbances. Consider an alternative agent if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Escitalopram with Ezogabine?
MediHelp rates the interaction as moderate. Escitalopram and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation and escitalopram also lengthens the QT interval. Combined use may increase proarrhythmic risk.
How serious is the interaction between Escitalopram and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG at baseline and during dose titration, and correct electrolyte disturbances. Consider an alternative agent if the QTc becomes prolonged.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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