Drug interactions
Escitalopram + Flurbiprofen
Severity: Moderate
Escitalopram and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Escitalopram reduces platelet serotonin content and impairs aggregation, and flurbiprofen adds antiplatelet action and gastric irritation. Together they increase the risk of upper GI bleeding.
What this interaction means in plain words
Escitalopram and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive platelet dysfunction (SSRI serotonin depletion plus COX-1 inhibition) with NSAID mucosal injury.
What to do
Consider gastroprotection with a proton pump inhibitor, particularly in older patients or those with prior GI bleeding. Use the lowest effective NSAID dose and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Flurbiprofen?
MediHelp rates the interaction as moderate. Escitalopram and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Escitalopram reduces platelet serotonin content and impairs aggregation, and flurbiprofen adds antiplatelet action and gastric irritation. Together they increase the risk of upper GI bleeding.
How serious is the interaction between Escitalopram and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor, particularly in older patients or those with prior GI bleeding. Use the lowest effective NSAID dose and monitor for bleeding.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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