Drug interactions
Escitalopram + Glasdegib
Severity: Major
Escitalopram and Glasdegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib and escitalopram can each prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk is greater with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Escitalopram and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Escitalopram belongs to Central Nervous System; Glasdegib belongs to Oncology.
Why it happens
Additive QTc prolongation through cardiac repolarization effects.
What to do
Prefer an antidepressant with less QT effect; if combined, correct electrolytes and monitor ECG, adjusting glasdegib per labeling for QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Escitalopram with Glasdegib?
MediHelp rates the interaction as major. Escitalopram and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glasdegib and escitalopram can each prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk is greater with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Escitalopram and Glasdegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antidepressant with less QT effect; if combined, correct electrolytes and monitor ECG, adjusting glasdegib per labeling for QTc prolongation.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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