Drug interactions
Escitalopram + Ibrutinib
Severity: Moderate
Escitalopram and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and increases bleeding risk, and SSRIs such as escitalopram also reduce platelet aggregation. Combined use may raise the likelihood of clinically significant bleeding.
What this interaction means in plain words
Escitalopram and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Ibrutinib belongs to Oncology.
Why it happens
Additive impairment of platelet function: BTK inhibition by ibrutinib and depletion of platelet serotonin by escitalopram.
What to do
Monitor for bruising, gastrointestinal bleeding, and other hemorrhage. Review other antithrombotic agents and consider holding ibrutinib around procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Escitalopram with Ibrutinib?
MediHelp rates the interaction as moderate. Escitalopram and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and increases bleeding risk, and SSRIs such as escitalopram also reduce platelet aggregation. Combined use may raise the likelihood of clinically significant bleeding.
How serious is the interaction between Escitalopram and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, gastrointestinal bleeding, and other hemorrhage. Review other antithrombotic agents and consider holding ibrutinib around procedures.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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