Drug interactions
Escitalopram + Larotrectinib
Severity: Minor
Escitalopram and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory activity and is unlikely to change escitalopram exposure meaningfully. Any effect is expected to be small.
What this interaction means in plain words
Escitalopram and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Escitalopram belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition; effect on escitalopram is theoretical.
What to do
No dose adjustment is expected. Monitor for escitalopram adverse effects if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Escitalopram with Larotrectinib?
MediHelp rates the interaction as minor. Escitalopram and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory activity and is unlikely to change escitalopram exposure meaningfully. Any effect is expected to be small.
How serious is the interaction between Escitalopram and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected. Monitor for escitalopram adverse effects if symptoms emerge.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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