Drug interactions
Escitalopram + Meclofenamic acid
Severity: Moderate
Escitalopram and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs combined with NSAIDs raise the risk of gastrointestinal and other bleeding beyond that of either drug alone. The risk is greater in older patients and those with prior ulcers.
What this interaction means in plain words
Escitalopram and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
SSRIs deplete platelet serotonin and impair aggregation, while NSAIDs inhibit platelet thromboxane and damage gastric mucosa.
What to do
Watch for signs of GI bleeding, and consider adding a proton pump inhibitor in high-risk patients. Prefer paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Meclofenamic acid?
MediHelp rates the interaction as moderate. Escitalopram and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs combined with NSAIDs raise the risk of gastrointestinal and other bleeding beyond that of either drug alone. The risk is greater in older patients and those with prior ulcers.
How serious is the interaction between Escitalopram and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of GI bleeding, and consider adding a proton pump inhibitor in high-risk patients. Prefer paracetamol where suitable.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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