Drug interactions
Esketamine + Ganaxolone
Severity: Moderate
Esketamine and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone commonly causes somnolence and sedation, which may add to esketamine sedation and dissociation. This may lead to excessive drowsiness and impaired alertness.
What this interaction means in plain words
Esketamine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and NMDA antagonism.
What to do
Monitor sedation level during and after esketamine administration and reduce doses if oversedation occurs. Advise against driving or hazardous tasks that day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Ganaxolone
Frequently asked questions
Can I take Esketamine with Ganaxolone?
MediHelp rates the interaction as moderate. Esketamine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone commonly causes somnolence and sedation, which may add to esketamine sedation and dissociation. This may lead to excessive drowsiness and impaired alertness.
How serious is the interaction between Esketamine and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level during and after esketamine administration and reduce doses if oversedation occurs. Advise against driving or hazardous tasks that day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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