Drug interactions
Esketamine + Imipramine
Severity: Moderate
Esketamine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a sedating tricyclic antidepressant, and esketamine also causes sedation and can raise blood pressure and heart rate. Concurrent use may increase drowsiness and cardiovascular stimulation.
What this interaction means in plain words
Esketamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus possible additive sympathomimetic cardiovascular effects.
What to do
Monitor sedation and blood pressure before and after esketamine dosing. Adjust the tricyclic dose if excessive sedation or hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Esketamine with Imipramine?
MediHelp rates the interaction as moderate. Esketamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a sedating tricyclic antidepressant, and esketamine also causes sedation and can raise blood pressure and heart rate. Concurrent use may increase drowsiness and cardiovascular stimulation.
How serious is the interaction between Esketamine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure before and after esketamine dosing. Adjust the tricyclic dose if excessive sedation or hypertension occurs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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