Drug interactions
Esketamine + Scopolamine
Severity: Moderate
Esketamine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine is an anticholinergic with sedative and cognitive effects, and combining it with esketamine may increase drowsiness, confusion and dissociative symptoms. Older patients are most at risk.
What this interaction means in plain words
Esketamine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive CNS effects from central muscarinic blockade and NMDA antagonism.
What to do
Monitor sedation and mental status after dosing, and avoid scopolamine where alternatives exist, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Scopolamine
Frequently asked questions
Can I take Esketamine with Scopolamine?
MediHelp rates the interaction as moderate. Esketamine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scopolamine is an anticholinergic with sedative and cognitive effects, and combining it with esketamine may increase drowsiness, confusion and dissociative symptoms. Older patients are most at risk.
How serious is the interaction between Esketamine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and mental status after dosing, and avoid scopolamine where alternatives exist, especially in older adults.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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