Drug interactions
Esketamine intranasal + Imipramine
Severity: Moderate
Esketamine intranasal and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and esketamine also raises blood pressure. Their combination may add to impaired alertness and cardiovascular stress.
What this interaction means in plain words
Esketamine intranasal and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, with esketamine-induced blood pressure elevation on top of noradrenergic effects of imipramine.
What to do
Monitor blood pressure and level of sedation before and after each esketamine dose. Advise the patient not to drive until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Imipramine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, and esketamine also raises blood pressure. Their combination may add to impaired alertness and cardiovascular stress.
How serious is the interaction between Esketamine intranasal and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and level of sedation before and after each esketamine dose. Advise the patient not to drive until the next day after a restful sleep.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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