Drug interactions
Esketamine intranasal + Isocarboxazid
Severity: Major
Esketamine intranasal and Isocarboxazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine can raise blood pressure and heart rate, and MAO inhibitors enhance sympathomimetic effects, so the combination may cause hypertensive reactions. Labeling advises monitoring blood pressure when combined with MAO inhibitors.
What this interaction means in plain words
Esketamine intranasal and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive sympathetic stimulation, as MAO inhibition increases catecholamine availability while esketamine raises sympathetic tone.
What to do
Measure blood pressure before and after each esketamine dose and avoid use if baseline blood pressure is elevated or if a hypertensive crisis is a concern.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Isocarboxazid?
MediHelp rates the interaction as major. Esketamine intranasal and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esketamine can raise blood pressure and heart rate, and MAO inhibitors enhance sympathomimetic effects, so the combination may cause hypertensive reactions. Labeling advises monitoring blood pressure when combined with MAO inhibitors.
How serious is the interaction between Esketamine intranasal and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure blood pressure before and after each esketamine dose and avoid use if baseline blood pressure is elevated or if a hypertensive crisis is a concern.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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