Drug interactions
Esketamine intranasal + Lorazepam
Severity: Moderate
Esketamine intranasal and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and together they may deepen drowsiness and impair psychomotor function after esketamine dosing.
What this interaction means in plain words
Esketamine intranasal and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Monitor sedation and vital signs during and after esketamine sessions and extend observation if sedation persists. Consider reducing the lorazepam dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Esketamine intranasal with Lorazepam?
MediHelp rates the interaction as moderate. Esketamine intranasal and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and together they may deepen drowsiness and impair psychomotor function after esketamine dosing.
How serious is the interaction between Esketamine intranasal and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and vital signs during and after esketamine sessions and extend observation if sedation persists. Consider reducing the lorazepam dose if oversedation occurs.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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