Drug interactions
Esketamine intranasal + Methadone
Severity: Moderate
Esketamine intranasal and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine and methadone both cause sedation, and together they may cause profound sedation or respiratory depression. Esketamine can also cause dissociation and blood pressure elevation.
What this interaction means in plain words
Esketamine intranasal and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Observe patients for sedation and respiratory depression during and after esketamine dosing. Review the need for other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Methadone?
MediHelp rates the interaction as moderate. Esketamine intranasal and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine and methadone both cause sedation, and together they may cause profound sedation or respiratory depression. Esketamine can also cause dissociation and blood pressure elevation.
How serious is the interaction between Esketamine intranasal and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe patients for sedation and respiratory depression during and after esketamine dosing. Review the need for other CNS depressants.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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