Drug interactions
Esketamine intranasal + Pseudoephedrine
Severity: Moderate
Esketamine intranasal and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine transiently raises blood pressure after dosing, and a sympathomimetic decongestant may add to this effect. The additive rise is relevant for patients with hypertension or cardiovascular disease.
What this interaction means in plain words
Esketamine intranasal and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pressor effects from esketamine's sympathetic stimulation and pseudoephedrine's indirect adrenergic action.
What to do
Check blood pressure before dosing and monitor afterward as per esketamine labeling. Delay or avoid pseudoephedrine around treatment sessions if baseline blood pressure is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Pseudoephedrine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine transiently raises blood pressure after dosing, and a sympathomimetic decongestant may add to this effect. The additive rise is relevant for patients with hypertension or cardiovascular disease.
How serious is the interaction between Esketamine intranasal and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before dosing and monitor afterward as per esketamine labeling. Delay or avoid pseudoephedrine around treatment sessions if baseline blood pressure is elevated.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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