Drug interactions
Esketamine intranasal + Scopolamine
Severity: Moderate
Esketamine intranasal and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and blood pressure increases, and scopolamine adds central sedative and anticholinergic effects. Combined use may intensify drowsiness and cognitive impairment.
What this interaction means in plain words
Esketamine intranasal and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and cognitive effects from NMDA antagonism and central muscarinic blockade.
What to do
Monitor sedation and mental status during and after esketamine dosing, and avoid driving until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Esketamine intranasal with Scopolamine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and blood pressure increases, and scopolamine adds central sedative and anticholinergic effects. Combined use may intensify drowsiness and cognitive impairment.
How serious is the interaction between Esketamine intranasal and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and mental status during and after esketamine dosing, and avoid driving until the next day after a restful sleep.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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