Drug interactions
Estazolam + Imipramine
Severity: Moderate
Estazolam and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a benzodiazepine hypnotic and imipramine is a sedating tricyclic. Together they produce additive CNS depression, with daytime drowsiness, dizziness, impaired psychomotor performance and falls, particularly in older adults.
What this interaction means in plain words
Estazolam and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and antihistaminic/anticholinergic tricyclic effects.
What to do
Use the lowest effective doses and monitor for oversedation and psychomotor impairment. Be especially cautious in older patients and advise against driving until tolerance is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Estazolam with Imipramine?
MediHelp rates the interaction as moderate. Estazolam and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estazolam is a benzodiazepine hypnotic and imipramine is a sedating tricyclic. Together they produce additive CNS depression, with daytime drowsiness, dizziness, impaired psychomotor performance and falls, particularly in older adults.
How serious is the interaction between Estazolam and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and psychomotor impairment. Be especially cautious in older patients and advise against driving until tolerance is known.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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