Drug interactions
Estazolam + Lorazepam
Severity: Moderate
Estazolam and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so combining them gives additive sedation, impaired coordination and respiratory depression without therapeutic advantage. The risk is higher in older or frail patients and with other depressants.
What this interaction means in plain words
Estazolam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive positive allosteric modulation of GABA-A receptors.
What to do
Avoid concurrent use of two benzodiazepines; if a switch is being made, taper one while introducing the other and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Estazolam and Lorazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lorazepam
Frequently asked questions
Can I take Estazolam with Lorazepam?
MediHelp rates the interaction as moderate. Estazolam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so combining them gives additive sedation, impaired coordination and respiratory depression without therapeutic advantage. The risk is higher in older or frail patients and with other depressants.
How serious is the interaction between Estazolam and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines; if a switch is being made, taper one while introducing the other and monitor for oversedation.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
